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Copyright notice. This article has been cited by other articles in PMC. Activation of beef heart mitochondrial adenosine triphosphatase by 2,4-dinitrophenol. Uncoupling of oxidative phosphorylation. Biochim Biophys Acta. The interaction of highly active uncouplers with mitochondria. Studies on the mechanism of uncoupling by amine local anesthetics. Evidence for mitochondrial proton transport mediated by lipophilic ion pairs.
J Biol Chem. Uncouplers of oxidative phosphorylation 1. These compounds through increasing the permeability of the IMM Failure of formation of the electrochemical gradient ATP formation stops while oxidation proceeds.
A- Uncouplers 4. Dinitrocresol 3. Snake venoms phospholipases 4. Pentachlorophenol 5. All enzymes participating in biological oxidation belong to class oxidoreductase. Major categories are: 1. Oxidases 2. Dehydrogenases 3.
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This uncoupling is a hormonally controlled process based on the presence of a mitochondrial proton channel called thermogenin. The hormone norepinephrine increases production of free fatty acids, which open the thermogenin channel.
This allows protons to ow from the intermembrane space back into the matrix without having to go through ATP synthase. Because of this, the electron transport chain can keep chugging away, ATP levels do not build up, there is no reduction in respiration rate, and the excess energy not being used in ATP production is released as heat.
Its mechanism of action derived from its ability to carry and release protons as it freely diffused through the mitochondrial membrane since it is a small hydrophobic molecule.
As this continues, cells catabolize more and more stores of carbohydrates and fats, which is the reason for the interest by dieters.
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